Fever in adults, differential diagnosis and administration of antipyretics

Fever: beneficial and detrimental effects of antipyretics.

Although various forms of therapy have been used, since antiquity, to lower the temperature of febrile patients, it is still not known whether the benefits of antipyretic therapy outweigh its risks. Justifications for the use of antipyretic drugs, and the evidence pertaining to these rationales, are examined. Antipyretic therapy in sepsis, and adverse effects of antipyretic medications, are als...

etiology, significance, diagnosis and treatment of bruxiam

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Fever: Its Pathology and Treatment by Antipyretics

Antipyretics: mechanisms of action and clinical use in fever suppression.

Fever is a complex physiologic response triggered by infectious or aseptic stimuli. Elevations in body temperature occur when concentrations of prostaglandin E(2) (PGE(2)) increase within certain areas of the brain. These elevations alter the firing rate of neurons that control thermoregulation in the hypothalamus. Although fever benefits the nonspecific immune response to invading microorganis...

Available evidence does not support routine administration of antipyretics to reduce duration of fever or illness.

Fever is a common occurrence in adults and children in community and healthcare settings. Despite this, it does not seem to be common knowledge that fever is a natural response to an invading organism and that most fevers are associated with self-limiting viral illnesses.1–3 Many health professionals and the general public see fever as an illness in itself not as a highly coordinated protective...